Novak Djokovic lost in the third round to Alexei Popyrin in what was his earliest defeat at the US Open since 2006 and earliest defeat at any major since the 2017 Australian Open.Since then the dominance of Sinner and Alcaraz has continued with the Italian lifting both the Australian Open and Wimbledon this year. Alcaraz has won the French Open and narrowly lost in that Wimbledon final.